The E2F5 repressor is an activator of E6/E7 transcription and of the S-phase entry in HPV18-associated cells

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

Jan M.M. Walboomers, Marcel V. Jacobs, M. Michele Manos et al. · The Journal of Pathology · 1999 · 9K citations · Full text

Medicine, Oncology, Pathology +16

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

Nicholas J. Dyson, Peter M. Howley, Karl Münger et al. · Science · 1989 · 3.1K citations

Life Sciences, Molecular Biology, Oncology +17

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

Martin Scheffner, Jon M. Huibregtse, Richard D. Vierstra et al. · Cell · 1993 · 2.4K citations

Life Sciences, Cancer Biology, Molecular Biology +15

E2F integrates cell cycle progression with DNA repair, replication, and G ₂ /M checkpoints

Bing Ren, Hieu Cam, Yasuhiko Takahashi et al. · Genes & Development · 2002 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

D. Gale Johnson, James K. Schwarz, W. Douglas Cress et al. · Nature · 1993 · 953 citations

Life Sciences, Cell Biology, Molecular Biology +15