A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (<scp>DS2</scp>) at human recombinant and rodent native<scp>GABA<sub>A</sub></scp>receptors - Concepedia

Concepedia

Publication | Open Access

A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (<scp>DS2</scp>) at human recombinant and rodent native<scp>GABA<sub>A</sub></scp>receptors

DOI Full Paper Access

81

Citations

62

References

2012

Year

ML Jensen, AR Brown, Delia Belelli, JJ Lambert, N.R. Mirza

British Journal of Pharmacology

Abstract

DS2 is the first PAM selective for α4/6βxδ receptors, providing a novel tool to investigate extrasynaptic δ-GABA(A) receptors. The effects of DS2 are mediated by an unknown site leading to GABA(A) receptor isoform selectivity.

References

	Year	Citations

Page 1