Exploring Nonnatural Evolutionary Pathways by Saturation Mutagenesis: Rapid Improvement of Protein Function

The Neutral Theory of Molecular Evolution

Scientific American · 1979 · 7.8K citations

Life Sciences, Biology, Evolutionary Biology +14

Rapid evolution of a protein in vitro by DNA shuffling

Willem P.C. Stemmer · Nature · 1994 · 1.9K citations

Life Sciences, Genetics, Molecular Biology +10

Principles of protein structure

Journal of Steroid Biochemistry · 1980 · 1.1K citations

Life Sciences, Biochemistry, Biophysics +12

Design by Directed Evolution

Frances H. Arnold · Accounts of Chemical Research · 1998 · 733 citations

Pharmacy, Chemical Engineering, Chemistry +6

A method for random mutagenesis of a defined DNA segment using a modified polymerase chain reaction

DW Leung, E Chen, Goeddel Dv · Medical Entomology and Zoology · 1989 · 612 citations

Life Sciences, Genetics, Molecular Biology +13