Concepedia

Design by Directed Evolution

Frances H. Arnold

Accounts of Chemical Research · 1998 · 733 citations · 19 references

DOI

Concepts

Abstract

An Introduction to ªIrrationalº Design The stunning array of features and functions exhibited by proteins in nature should convince most scientists of the power of evolutionary design processes. Natural selection acting on populations over long periods of time has

References

19

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Rapid evolution of a protein in vitro by DNA shuffling

Willem P.C. Stemmer · Nature · 1994 · 1.9K citations

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DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution.

Willem PC Stemmer · Proceedings of the National Academy of Sciences · 1994 · 1.3K citations

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Improved Green Fluorescent Protein by Molecular Evolution Using DNA Shuffling

Andreas Crameri, Erik A. Whitehorn, Emily Tate et al. · Nature Biotechnology · 1996 · 1.2K citations

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DNA shuffling of a family of genes from diverse species accelerates directed evolution

Andreas Crameri, Sun-Ai Raillard, Ericka Bermudez et al. · Nature · 1998 · 828 citations

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