The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase

Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.

Ingrid Hoffmann, Paul R. Clarke, María Jesús Marcote et al. · The EMBO Journal · 1993 · 674 citations

Signal Transduction, Signaling Pathway, Cell Division +13

Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15

Paul R. Mueller, Thomas R. Coleman, Akiko Kumagai et al. · Science · 1995 · 668 citations

Molecular Regulation, Cell Cycle, Cellular Physiology +16

<i>Polo</i>, a mitotic mutant of <i>Drosophila</i> displaying abnormal spindle poles

Cláudio E. Sunkel, David M. Glover · Journal of Cell Science · 1988 · 561 citations

The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system

Akiko Kumagai, William G. Dunphy · Cell · 1991 · 506 citations

Signal Transduction, Signaling Pathway, Cell Regulation +11

Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from <b> <i>Xenopus</i> </b> Egg Extracts

Akiko Kumagai, William G. Dunphy · Science · 1996 · 502 citations

Molecular Regulation, Genetics, Molecular Biology +23