Dual Inhibition of mTOR and Estrogen Receptor Signaling<i>In vitro</i>Induces Cell Death in Models of Breast Cancer

Abstract

mTOR signaling is required for estrogen-induced breast tumor cell proliferation. Moreover, RAD001-letrozole combinations can act in a synergistic manner to inhibit proliferation and trigger apoptotic cell death. This combination holds promise for the treatment of hormone-dependent breast cancers.