Sabine Zumstein-Mecker

Dual Inhibition of mTOR and Estrogen Receptor Signaling<i>In vitro</i>Induces Cell Death in Models of Breast Cancer

Anne Boulay, Joëlle Rudloff, Jingjing Ye et al. · Clinical Cancer Research · 2005 · 335 citations · Full text

Medicine, Oncology, Pharmacology +17

Antitumor Efficacy of Intermittent Treatment Schedules with the Rapamycin Derivative RAD001 Correlates with Prolonged Inactivation of Ribosomal Protein S6 Kinase 1 in Peripheral Blood Mononuclear Cells

Anne Boulay, Sabine Zumstein-Mecker, Christine Stephan et al. · Cancer Research · 2004 · 319 citations · Full text

Medicine, Oncology, Pharmacology +14

Identifying Optimal Biologic Doses of Everolimus (RAD001) in Patients With Cancer Based on the Modeling of Preclinical and Clinical Pharmacokinetic and Pharmacodynamic Data

Chiaki Tanaka, Terence O’Reilly, John M. Kovarik et al. · Journal of Clinical Oncology · 2008 · 210 citations

Medicine, Pharmacokinetics, Pharmacology +17

Inhibition of Cyclin-Dependent Kinase 4 (Cdk4) by Fascaplysin, a Marine Natural Product

Rajeev Soni, Lionel Muller, Pascal Furet et al. · Biochemical and Biophysical Research Communications · 2000 · 164 citations

Life Sciences, Biochemistry, Marine Biology +14

Everolimus suppresses cancellous bone loss, bone resorption, and cathepsin K expression by osteoclasts

Michaela Kneissel, Ngoc-Hong Luong-Nguyen, Myma Baptist et al. · Bone · 2004 · 161 citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +16