Christine Stephan

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

E. Robert McDonald, Antoine de Weck, Michael R. Schlabach et al. · Cell · 2017 · 701 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +17

Antitumor Efficacy of Intermittent Treatment Schedules with the Rapamycin Derivative RAD001 Correlates with Prolonged Inactivation of Ribosomal Protein S6 Kinase 1 in Peripheral Blood Mononuclear Cells

Anne Boulay, Sabine Zumstein-Mecker, Christine Stephan et al. · Cancer Research · 2004 · 319 citations · Full text

Medicine, Oncology, Pharmacology +14

Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition

Madlaina Breuleux, Matthieu Klopfenstein, Christine Stephan et al. · Molecular Cancer Therapeutics · 2009 · 241 citations · Full text

Medicine, Oncology, Pharmacology +14

Identifying Optimal Biologic Doses of Everolimus (RAD001) in Patients With Cancer Based on the Modeling of Preclinical and Clinical Pharmacokinetic and Pharmacodynamic Data

Chiaki Tanaka, Terence O’Reilly, John M. Kovarik et al. · Journal of Clinical Oncology · 2008 · 210 citations

Medicine, Pharmacokinetics, Pharmacology +17

Role of mitochondria and C‐terminal membrane anchor of Bcl‐2 in Bax induced growth arrest and mortality in <i>Saccharomyces cerevisiae</i>

William Greenhalf, Christine Stephan, Bhabatosh Chaudhuri · FEBS Letters · 1996 · 179 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15