Concepedia

Relative Contributions of Presystemic and Systemic Peptidases to Oral Exposure of a Novel Metabotropic Glutamate 2/3 Receptor Agonist (LY404039) After Oral Administration of Prodrug Pomaglumetad Methionil (LY2140023)

William F. Annes, Amanda Long, Jennifer Witcher, Mosun Ayan‐Oshodi, Mary Pat Knadler, Wei Zhang, Malcolm I. Mitchell, Karen Cornelissen, Stephen D. Hall

Journal of Pharmaceutical Sciences · 2014 · 20 citations · 7 references

DOI

Concepts

References

7

Attenuation of the Neuropsychiatric Effects of Ketamine With Lamotrigine

Amit Anand, Dennis S. Charney, Dan A. Oren et al. · Archives of General Psychiatry · 2000 · 425 citations

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Direct Evidence for Peptide Transporter (PepT1)-Mediated Uptake of a Nonpeptide Prodrug, Valacyclovir

Praveen Balimane, Ikumi Tamai, Ailan Guo et al. · Biochemical and Biophysical Research Communications · 1998 · 211 citations · Full text

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Pharmacological and Pharmacokinetic Properties of a Structurally Novel, Potent, and Selective Metabotropic Glutamate 2/3 Receptor Agonist: In Vitro Characterization of Agonist (–)-(1 R,4 S,5 S,6 S)-4-Amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic Acid (LY404039)

Linda M. Rorick‐Kehn, Bryan G. Johnson, Jennifer Burkey et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 93 citations

, , +14

Synthesis and Metabotropic Glutamate Receptor Activity of S-Oxidized Variants of (−)-4-Amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate:  Identification of Potent, Selective, and Orally Bioavailable Agonists for mGlu2/3 Receptors

James A. Monn, Steven M. Massey, Matthew J. Valli et al. · Journal of Medicinal Chemistry · 2006 · 66 citations · Full text

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Current prodrug strategies for improving oral absorption of nucleoside analogues

Youxi Zhang, Yikun Gao, Haiying Ma · Asian Journal of Pharmaceutical Sciences · 2014 · 45 citations · Full text

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