Concepedia

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Oncolytic Virus-Mediated Manipulation of DNA Damage Responses: Synergy With Chemotherapy in Killing Glioblastoma Stem Cells

DOI

113

Citations

45

References

2011

Year

Ryuichi Kanai, Samuel D. Rabkin, Stephen Yip, Donatella Sgubin, Cécile Zaupa, Yuichi Hirose, David N. Louis, Hiroaki Wakimoto, Robert L. Martuza
JNCI Journal of the National Cancer Institute

Abstract

The combination of G47Δ and TMZ acts synergistically in killing GSCs through oHSV-mediated manipulation of DNA damage responses. This strategy is highly efficacious in representative preclinical models and warrants clinical translation.

References

YearCitations

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