Yuichi Hirose

p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells.

Yuichi Hirose, Mitchel S. Berger, Russell O. Pieper · PubMed · 2001 · 343 citations

G2/m Arrest, Apoptosis, Cell Death +20

Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma.

Yukihiko Sonoda, T. Ozawa, Yuichi Hirose et al. · PubMed · 2001 · 281 citations

Glioma Formation, Normal Human Astrocytes, Cerebral Organoid +24

Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells.

Yuichi Hirose, Mitchel S. Berger, Russell O. Pieper · PubMed · 2001 · 236 citations

Apoptosis, Cell Death, Tmz-induced Mmr +19

Akt Activation Suppresses Chk2-Mediated, Methylating Agent–Induced G2 Arrest and Protects from Temozolomide-Induced Mitotic Catastrophe and Cellular Senescence

Yuichi Hirose, Makoto Katayama, Olga K. Mirzoeva et al. · Cancer Research · 2005 · 151 citations · Full text

Apoptosis, Cell Death, Temozolomide-treated Cells +19

Astroblastoma: Clinicopathologic Features and Chromosomal Abnormalities Defined by Comparative Genomic Hybridization

Daniel J. Brat, Yuichi Hirose, Kenneth J. Cohen et al. · Brain Pathology · 2000 · 147 citations · Full text