Yuichi Hirose

p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells.

Yuichi Hirose, Mitchel S. Berger, Russell O. Pieper · PubMed · 2001 · 343 citations

Life Sciences, Molecular Biology, Oncology +17

Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma.

Yukihiko Sonoda, T. Ozawa, Yuichi Hirose et al. · PubMed · 2001 · 281 citations

Medicine, Molecular Genetics, Oncology +15

Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells.

Yuichi Hirose, Mitchel S. Berger, Russell O. Pieper · PubMed · 2001 · 236 citations

Medicine, Cancer Biology, Oncology +17

Akt Activation Suppresses Chk2-Mediated, Methylating Agent–Induced G2 Arrest and Protects from Temozolomide-Induced Mitotic Catastrophe and Cellular Senescence

Yuichi Hirose, Makoto Katayama, Olga K. Mirzoeva et al. · Cancer Research · 2005 · 152 citations · Full text

Medicine, Oncology, Pharmacology +15

Astroblastoma: Clinicopathologic Features and Chromosomal Abnormalities Defined by Comparative Genomic Hybridization

Daniel J. Brat, Yuichi Hirose, Kenneth J. Cohen et al. · Brain Pathology · 2000 · 148 citations · Full text

Medicine, Oncology, Pathology +17