Concepedia

A Novel Strategy for Physiologically Based Predictions of Human Pharmacokinetics

Hannah M. Jones, Neil Parrott, Karin Jorga, Thierry Lav

Clinical Pharmacokinetics · 2006 · 348 citations · 62 references

DOI

Concepts

References

62

Physicochemical High Throughput Screening:  Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes

Manfred Kansy, Frank Senner, Klaus Gubernator · Journal of Medicinal Chemistry · 1998 · 1.3K citations

, , +16

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

, , +17

Characterization of Interintestinal and Intraintestinal Variations in Human CYP3A-Dependent Metabolism

Mary F. Paine, Mehraneh Khalighi, Jeannine M. Fisher et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 792 citations

, , +17

Physiologically Based Pharmacokinetic Modeling 1: Predicting the Tissue Distribution of Moderate-to-Strong Bases

Trudy Rodgers, David E. Leahy, Malcolm Rowland · Journal of Pharmaceutical Sciences · 2005 · 774 citations

, , +13

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data

Kaoxiang Sun · Chinese New Drugs Journal · 2005 · 764 citations

, , +14