Concepedia

CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members

Eirini Trompouki, Eudoxia Hatzivassiliou, Theodore Tsichritzis, Hannah Farmer, Alan Ashworth, George Mosialos

Nature · 2003 · 968 citations · 23 references

DOIFull text

Open access

Concepts

References

23

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Chen Wang, Li Deng, Mei Hong et al. · Nature · 2001 · 2.1K citations

, , +5

Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain

Li Deng, Chen Wang, Erika Spencer et al. · Cell · 2000 · 1.9K citations · Full text

, , +16

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

Mark Lomaga, Wen‐Chen Yeh, Ildiko Sarosi et al. · Genes & Development · 1999 · 1.3K citations · Full text

, , +12

The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

George Mosialos, Mark Birkenbacht, Ramana Yalamanchill et al. · Cell · 1995 · 989 citations · Full text

, , +16

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

Thijn R. Brummelkamp, Sebastian Nijman, Annette M.G. Dirac et al. · Nature · 2003 · 956 citations · Full text

, , +12