Sebastian Nijman

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

Johan de Rooij, Fried Zwartkruis, Mark H. G. Verheijen et al. · Nature · 1998 · 2K citations

Signal Transduction, Molecular Physiology, Biochemistry +7

Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma

Yujin Hoshida, Sebastian Nijman, Masahiro Kobayashi et al. · Cancer Research · 2009 · 1.2K citations · Full text

Engineering, Human Hepatocellular Carcinoma, Pathology +19

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

Thijn R. Brummelkamp, Sebastian Nijman, Annette M.G. Dirac et al. · Nature · 2003 · 949 citations · Full text

Oncology, Cell Signaling, Medicine +10

The Deubiquitinating Enzyme USP1 Regulates the Fanconi Anemia Pathway

Sebastian Nijman, Tony T. Huang, Annette M.G. Dirac et al. · Molecular Cell · 2005 · 588 citations · Full text

Deubiquitinating Enzyme Usp1, Protein Function, Cellular Biochemistry +1

Regulation of monoubiquitinated PCNA by DUB autocleavage

Tony T. Huang, Sebastian Nijman, Kanchan D. Mirchandani et al. · Nature Cell Biology · 2006 · 585 citations · Full text

Natural Sciences, Dub Autocleavage, Molecular Biology +3