Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura et al. · Nature · 1988 · 10.8K citations · Full text

Life Sciences, Cell Biology, Physiology +9

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

Akiko Inoue, Masashi Yanagisawa, Sadao Kimura et al. · Proceedings of the National Academy of Sciences · 1989 · 2.5K citations · Full text

Life Sciences, Genetics, Molecular Biology +10

Retinoic Acid Embryopathy

Edward J. Lammer, Diane T. Chen, Richard M. Hoar et al. · New England Journal of Medicine · 1985 · 1.9K citations

Medicine, Obstetrics, Pharmacology +14

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi · Nature · 1988 · 1.7K citations

Medicine, Genetics, Molecular Genetics +15

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

Gilberto De Nucci, Ranjeny Thomas, Pedro D’Orléans-Juste et al. · Proceedings of the National Academy of Sciences · 1988 · 1.4K citations · Full text

Medicine, Pharmacology, Physiology +12