Ryozo Nagai

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa et al. · Nature · 1997 · 3.8K citations

Knockout Mouse, Mendelian Disorder, Aging +8

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

Toshimasa Yamauchi, Junji Kamon, Yusuke Ito et al. · Nature · 2003 · 3.1K citations

Obesity, Metabolic Syndrome, Biochemistry +7

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

Satoshi Nishimura, Ichiro Manabe, Koji Eto et al. · Nature Medicine · 2009 · 2.2K citations

Obesity, Metabolic Syndrome, Inflammation +8

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

Toshimasa Yamauchi, Yasunori Nio, Toshiyuki Maki et al. · Nature Medicine · 2007 · 1.4K citations

Metabolic Syndrome, Systems Biology, Signal Transduction +8

PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

Naoto Kubota, Yasuo Terauchi, Hiroshi Miki et al. · Molecular Cell · 1999 · 1.4K citations · Full text

Insulin Resistance, Obesity, Metabolic Syndrome +10