Concepedia

Endothelin-mediated Vasoconstriction

Endothelin-Mediated Vasoconstriction is a physiological mechanism in the regulation of liver blood flow wherein vasoconstriction of hepatic sinusoids and portal tracts is induced by the binding of endothelin peptides, primarily endothelin-1, to vascular smooth muscle receptors, distinguishing it from other vasoconstrictive pathways by its origin in endothelial-derived signaling and potent, sustained vascular tone modulation.

2.4K

Publications

139.9K

Citations

8.2K

Authors

1.5K

Institutions

Publications per year

2017–2026

79

Parents

Publications

2.4K

Bosentan Therapy for Pulmonary Arterial Hypertension

Lewis J. Rubin, David B. Badesch, Robyn J. Barst et al. · New England Journal of Medicine · 2002 · 2.7K citations · Full text

, , +17

Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension

Adel Giaid, Masashi Yanagisawa, David Langleben et al. · New England Journal of Medicine · 1993 · 1.8K citations · Full text

, , +11

Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study

Richard N. Channick, G Simonneau, Olivier Sitbon et al. · The Lancet · 2001 · 1.5K citations

, , +13

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

Gilberto De Nucci, Ranjeny Thomas, Pedro D’Orléans-Juste et al. · Proceedings of the National Academy of Sciences · 1988 · 1.4K citations · Full text

, , +12

Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1

Yukiko Kurihara, Hiroki Kurihara, Hiroshi Suzuki et al. · Nature · 1994 · 992 citations

, , +9

1–5 of 2.4K

Authors

8.2K

  1. MY
    Masashi Yanagisawa

    The University of Texas Southwestern Medical Center, United States

    42 publications · 7.3K citations

    33

    h-index

  2. KG
    Katsutoshi Goto

    University of Tsukuba, Japan

    33 publications · 3.6K citations

    26

    h-index

  3. JP
    John Pernow

    Karolinska Institutet, Sweden

    31 publications · 1.3K citations

    25

    h-index

  4. LE
    Lars Edvinsson

    Lund University, Sweden

    42 publications · 1.4K citations

    24

    h-index

  5. MC
    Martine Clozel

    Roche (Switzerland), Switzerland

    25 publications · 2.7K citations

    23

    h-index

1–5 of 8.2K

Institutions

1.5K

  1. University of Tsukuba

    Tsukuba, Japan

    32 h-index

    268 publications

    32.3K citations

  2. Karolinska Institutet

    Stockholm, Sweden

    30 h-index

    160 publications

    6.8K citations

  3. Roche (Switzerland)

    Basel, Switzerland

    29 h-index

    127 publications

    18.7K citations

  4. Mayo Clinic

    Rochester, United States

    26 h-index

    179 publications

    15.9K citations

  5. Lund University

    Lund, Sweden

    26 h-index

    154 publications

    5.8K citations

  6. University College London

    London, United Kingdom

    25 h-index

    109 publications

    9K citations

  7. William Harvey Research Institute

    London, United Kingdom

    24 h-index

    97 publications

    16.6K citations

  8. Karolinska University Hospital

    Stockholm, Sweden

    24 h-index

    105 publications

    3.5K citations

1–8 of 1.5K

Venues

  1. Circulation

    60 publications · 9.8K citations

    49

    h-index

  2. Hypertension

    82 publications · 6.4K citations

    46

    h-index

  3. British Journal of Pharmacology

    BJP · 108 publications · 5.4K citations

    45

    h-index

  4. Journal of Cardiovascular Pharmacology

    160 publications · 5.4K citations

    41

    h-index

  5. 37

    h-index

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