Concepedia

Different Contributions of Cytochrome P450 2C19 and 3A4 in the Oxidation of Omeprazole by Human Liver Microsomes: Effects of Contents of These Two Forms in Individual Human Samples

Hiroshi Yamazaki, Kiyoshi Inoue, Peter Shaw, W J Checovich, F. Peter Guengerich, Tsutomu Shimada

Journal of Pharmacology and Experimental Therapeutics · 1997 · 132 citations · 45 references

References

45

The Carbon Monoxide-binding Pigment of Liver Microsomes

Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry · 1964 · 11.8K citations · Full text

Life Sciences, Biochemistry, Chemistry +8

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Medicine, Biochemistry, Pharmacology +15

Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese.

G. Wilkinson, Joyce Blaisdell, Urs Meyer et al. · Molecular Pharmacology · 1994 · 750 citations

Life Sciences, Genetics, Pharmacology +16

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

F. Peter Guengerich, M V Martin, Philippe Beaune et al. · Journal of Biological Chemistry · 1986 · 730 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Reactions and significance of cytochrome P-450 enzymes

F. Peter Guengerich · Journal of Biological Chemistry · 1991 · 603 citations · Full text

Life Sciences, Biochemistry, Enzyme Mechanism +16