Involvement of Organic Cation Transporter 1 in Hepatic and Intestinal Distribution of Metformin

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Mark R. Owen, E. Doran, Andrew P. Halestrap · Biochemical Journal · 2000 · 2.1K citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I

Mohamad-Yehia El-Mir, Véronique Nogueira, Éric Fontaine et al. · Journal of Biological Chemistry · 2000 · 1.4K citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Mechanism by which metformin reduces glucose production in type 2 diabetes.

Ripudaman S. Hundal, Sylvie Dufour, Didier Laurent et al. · Diabetes · 2000 · 1.1K citations · Full text

Life Sciences, Endocrinology, Physiology +17

Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy

Elsy Velázquez, Soaira Mendoza, T Hamer et al. · Metabolism · 1994 · 874 citations

Medicine, Endocrinology, Gynecology +17

Metformin reverses fatty liver disease in obese, leptin-deficient mice

Hui Lin, Shi Qi Yang, Christine Chuckaree et al. · Nature Medicine · 2000 · 679 citations

Medicine, Endocrinology, Pharmacology +14