B7 Costimulation and Intracellular Indoleamine‐2,3‐Dioxygenase Expression in Peripheral Blood of Healthy Pregnant and Pre‐Eclamptic Women

Abstract

Lower expression of B7-1 and B7-2 proteins on peripheral monocytes in PE might indicate a secondary regulatory mechanism in response to the ongoing systemic maternal inflammation. IDO plays an important role in the pregnancy-specific immune tolerance, and might be a contributing factor in the pathogenesis of PE.