Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Warren J. Strittmatter, Ann M. Saunders, D. E. Schmechel, +4

Proceedings of the National Academy of Sciences

Type 4GeneticsGenetic EpidemiologyNeurochemical BiomarkersSocial Sciences +16

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

Patrick L. McGeer, Shigeru Itagaki, Barry E. Boyes, +1

Neurology

Amyloid β-peptide is produced by cultured cells during normal metabolism

Christian Haass, Michael G. Schlossmacher, Albert Y. Hung, +8

Nature

Amyloid β-PeptideProtein ExpressionBiochemistryNatural SciencesProtein Biosynthesis +9

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

Peter Seubert, Carmen Vigo‐Pelfrey, Fred Esch, +12

Nature

Neurodegenerative DiseasesAlzheimer's DiseaseBiochemistryBioanalysisNeurochemical Biomarkers +4

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

D. E. Schmechel, Ann M. Saunders, Warren J. Strittmatter, +6

Proceedings of the National Academy of Sciences

Neurochemical BiomarkersAlzheimer's DiseaseProtein MisfoldingNeurologyLate-onset Alzheimer Disease +17

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

Mikio Shoji, Todd E. Golde, Jorge Ghiso, +8

Science

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

Xiao-Dan Cai, Todd E. Golde, Steven G. Younkin

Science

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

Patrick L. McGeer, Shigeru Itagaki, Hisao Tago, +1

Neuroscience Letters

Alzheimer TypeAlzheimer's DiseaseReactive MicrogliaSenile DementiaMedicine +10

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

Olli Saksela, David Moscatelli, Andreas Sommer, +1

The Journal of Cell Biology

Tissue EngineeringImmunologyGlycobiologyCellular PhysiologyInflammation +21

Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

Joseph Rogers, Judith Luber‐Narod, Scot Styren, +1

Neurobiology of Aging

Alzheimer's DiseaseMedicineDementiaImmunologyImmune System-associated Antigens +9