Amyloid β protein (Aβ) removal by neuroglial cells in culture

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Warren J. Strittmatter, Ann M. Saunders, D. E. Schmechel et al. · Proceedings of the National Academy of Sciences · 1993 · 4.3K citations · Full text

Type 4, Genetics, Genetic Epidemiology +18

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

Patrick L. McGeer, Shigeru Itagaki, Barry E. Boyes et al. · Neurology · 1988 · 2.9K citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

Christian Haass, Michael G. Schlossmacher, Albert Y. Hung et al. · Nature · 1992 · 1.9K citations

Amyloid β-Peptide, Protein Expression, Biochemistry +11

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

Peter Seubert, Carmen Vigo‐Pelfrey, Fred Esch et al. · Nature · 1992 · 1.7K citations

Neurodegenerative Diseases, Alzheimer's Disease, Biochemistry +6

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

D. E. Schmechel, Ann M. Saunders, Warren J. Strittmatter et al. · Proceedings of the National Academy of Sciences · 1993 · 1.5K citations · Full text

Neurochemical Biomarkers, Alzheimer's Disease, Protein Misfolding +19