Indoline and piperazine containing derivatives as a novel class of mixed D2/D4 receptor antagonists. Part 1: Identification and structure–activity relationships

Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain

Arvid Carlsson, Margit Lindqvist · Acta Pharmacologica et Toxicologica · 1963 · 2.1K citations

Molecular Pharmacology, Molecular Neuroscience, Neurophysiology +11

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

Hubert H.M. Van Tol, James R. Bunzow, Hong‐Chang Guan et al. · Nature · 1991 · 2K citations · Full text

Molecular Pharmacology, Psychiatry, Functional Selectivity +13

3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridine:  An Antagonist with High Affinity and Selectivity for the Human Dopamine D₄ Receptor

Janusz J. Kulagowski, Howard B. Broughton, Neil R. Curtis et al. · Journal of Medicinal Chemistry · 1996 · 257 citations · Full text

Altmetric Attention Score, Psychopharmacology, Pharmacotherapy +18

Isoindolinone enantiomers having affinity for the dopamine D4 receptor

Thomas R. Belliotti, Wouter A. Brink, Suzanne R. Kesten et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 209 citations · Full text

Isoindolinone Enantiomers, Functional Selectivity, Medicine +5

Design, Synthesis, and Evaluation of Chromen-2-ones as Potent and Selective Human Dopamine D4 Antagonists

Suzanne R. Kesten, Thomas G. Heffner, Stephen J. Johnson et al. · Journal of Medicinal Chemistry · 1999 · 110 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Selective Affinity +15