Howard B. Broughton

3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridine:  An Antagonist with High Affinity and Selectivity for the Human Dopamine D₄ Receptor

Janusz J. Kulagowski, Howard B. Broughton, Neil R. Curtis et al. · Journal of Medicinal Chemistry · 1996 · 257 citations · Full text

Medicine, Pharmacology, Neurochemistry +4

Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT_1D Receptor Ligands with Improved Pharmacokinetic Profiles

Monique B. van Niel, Ian Collins, Margaret S. Beer et al. · Journal of Medicinal Chemistry · 1999 · 157 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Identification of a Novel, Selective GABA_Aα5 Receptor Inverse Agonist Which Enhances Cognition

Mark S. Chambers, John Atack, Howard B. Broughton et al. · Journal of Medicinal Chemistry · 2003 · 140 citations · Full text

Medicine, Neuroscience, Pharmacology +16

The Chemical Basis of Serine Palmitoyltransferase Inhibition by Myriocin

John Wadsworth, David J. Clarke, S.A. McMahon et al. · Journal of the American Chemical Society · 2013 · 128 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Selection of heterocycles for drug design

Howard B. Broughton, Ian A. Watson · Journal of Molecular Graphics and Modelling · 2004 · 117 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12