Isoindolinone enantiomers having affinity for the dopamine D4 receptor

Thomas R. Belliotti, Wouter A. Brink, Suzanne R. Kesten, +8

Bioorganic & Medicinal Chemistry Letters

Isoindolinone EnantiomersFunctional SelectivityMedicineNeuropharmacologyPharmacotherapy +3

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

Douglas S. Johnson, Cory M. Stiff, Scott E. Lazerwith, +13

ACS Medicinal Chemistry Letters

Pharmaceutical ScienceMolecular PainPharmacotherapyPharmaceutical ChemistryRat Model +17

Design, Synthesis, and Evaluation of Chromen-2-ones as Potent and Selective Human Dopamine D4 Antagonists

Suzanne R. Kesten, Thomas G. Heffner, Stephen J. Johnson, +3

Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistrySelective AffinityCompound 22Biochemistry +13

Subtype-Selective <i>N</i>-Methyl-<scp>d</scp>-Aspartate Receptor Antagonists:  Synthesis and Biological Evaluation of 1-(Heteroarylalkynyl)-4-benzylpiperidines

Jonathan L. Wright, Tracy F. Gregory, Suzanne R. Kesten, +8

Journal of Medicinal Chemistry

Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)

Douglas S. Johnson, Kay Ahn, Suzanne R. Kesten, +12

Bioorganic & Medicinal Chemistry Letters

Bioorganic ChemistryBiochemistryNatural SciencesMedicineBenzothiophene Piperazine +6

Synthesis of <i>N-</i>Substituted 4-(4-Hydroxyphenyl)piperidines, 4-(4-Hydroxybenzyl)piperidines, and (±)-3-(4-Hydroxyphenyl)pyrrolidines:  Selective Antagonists at the 1<scp>a</scp>/2B NMDA Receptor Subtype

Anthony P. Guzikowski, Amir P. Tamiz, Manuel Acosta-Burruel, +11

Journal of Medicinal Chemistry

Combinatorial ChemistryPharmacotherapyExperimental PharmacologyMolecular PharmacologyOmega-phenyl Group +15

The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases

Lain‐Yen Hu, Peter A. Boxer, Suzanne R. Kesten, +26

Bioorganic & Medicinal Chemistry Letters

Neurodegenerative DiseasesBiochemistryMedicineRational Drug DesignPeptide Synthesis +5

Aminopyrimidines with High Affinity for Both Serotonin and Dopamine Receptors

David J. Wustrow, Thomas R. Belliotti, Shelly A. Glase, +14

Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryFunctional SelectivityMedicineMonoamine Neurotransmitters +12

The Discovery and Structure-Activity Relationships of 1,2,3,6-Tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine Autoreceptor Agonists and Potential Antipsychotic Agents

Jon L. Wright, Bradley W. Caprathe, Dennis M. Downing, +6

Journal of Medicinal Chemistry

Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligands

Thomas R. Belliotti, Suzanne R. Kesten, John R. Rubin, +5

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryFunctional SelectivityMedicine +7