Breast Cancer Proteins PALB2 and BRCA2 Stimulate Polymerase η in Recombination-Associated DNA Synthesis at Blocked Replication Forks

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Helen E. Bryant, Niklas Schultz, Huw D. Thomas et al. · Nature · 2005 · 5.1K citations

Tumor Biology, Oncology, Medicine +7

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η

Chikahide Masutani, Rika Kusumoto, Ayumi Yamada et al. · Nature · 1999 · 1.3K citations

Natural Sciences, Genetics, Dna Replication +7

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

Katharina Schlacher, Nicole Christ, Nicolas Siaud et al. · Cell · 2011 · 1.3K citations · Full text

Chromatin, Genome Instability, Natural Sciences +6

Biallelic Inactivation of <i>BRCA2</i> in Fanconi Anemia

Niall G. Howlett, Toshiyasu Taniguchi, Susan B. Olson et al. · Science · 2002 · 1.1K citations

Biallelic Inactivation, Genome Instability, Fanconi Anemia +12

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

Katharina Schlacher, Hong Wu, Maria Jasin · Cancer Cell · 2012 · 930 citations · Full text

Tumor Biology, Genome Instability, Cell Regulation +7