SUMOylation-Dependent Localization of IKKɛ in PML Nuclear Bodies Is Essential for Protection against DNA-Damage-Triggered Cell Death

IKKε and TBK1 are essential components of the IRF3 signaling pathway

Katherine A. Fitzgerald, Sarah M. McWhirter, L. Kerrie et al. · Nature Immunology · 2003 · 2.7K citations

Signal Transduction, Signaling Pathway, Cell Regulation +9

Atmospheric carbon dioxide concentrations over the past 60 million years

Paul N. Pearson, Martin R. Palmer · Nature · 2000 · 1.8K citations

Carbon Sequestration, Engineering, Atmospheric Science +7

Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

Sonia Sharma, Benjamin R. tenOever, Nathalie Grandvaux et al. · Science · 2003 · 1.7K citations

Ikappab Kinase, Signal Transduction, Rapid Induction +14

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

Mark Pearson, Roberta Carbone, Carla Sebastiani et al. · Nature · 2000 · 826 citations

P53 Acetylation, Oncogenic Ras, Cell Regulation +9

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

Michael H. Tatham, Marie‐Claude Geoffroy, Linnan Shen et al. · Nature Cell Biology · 2008 · 821 citations · Full text

Protein Function, Natural Sciences, Metalloprotein +8