RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

Michael H. Tatham, Marie‐Claude Geoffroy, Linnan Shen, +5

Nature Cell Biology

Protein FunctionNatural SciencesMetalloproteinArsenic-induced Pml DegradationMolecular Biology +6

NEDP1, a Highly Conserved Cysteine Protease That deNEDDylates Cullins

Heidi M. Mendoza, Linnan Shen, Catherine H. Botting, +4

Journal of Biological Chemistry

Ribosomal proteins are targets for the NEDD8 pathway

Dimitris P. Xirodimas, Anders Sundqvist, Akihiro Nakamura, +3

EMBO Reports

Natural SciencesMolecular BiologyNedd8 PathwayGene ExpressionProtein Synthesis

SUMO protease SENP1 induces isomerization of the scissile peptide bond

Linnan Shen, Michael H. Tatham, Changjiang Dong, +3

Nature Structural & Molecular Biology

Protein ChemistryProtein FunctionSignal TransductionBiochemistryProtein Assembly +7

Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1

Linnan Shen, Huanting Liu, Changjiang Dong, +3

The EMBO Journal

Protein ChemistryNedd8 Ubiquitin DiscriminationBiochemistryStructural BioinformaticsNatural Sciences +6

The SUMO protease SENP6 is a direct regulator of PML nuclear bodies

Neil Hattersley, Linnan Shen, Ellis Jaffray, +1

Molecular Biology of the Cell

Molecular RegulationMolecular BiologyPml NbsPml Nuclear BodiesPml-nuclear Bodies +15

Antibody RING-Mediated Destruction of Endogenous Proteins

Adel F.M. Ibrahim, Linnan Shen, Michael H. Tatham, +5

Molecular Cell

VCP/p97-associated proteins are binders and debranching enzymes of K48–K63-branched ubiquitin chains

Sven M. Lange, Matthew R. McFarland, Frédéric Lamoliatte, +12

Nature Structural & Molecular Biology

Comprehensive approach to study branched ubiquitin chains reveals roles for K48-K63 branches in VCP/p97-related processes

Sven M. Lange, Matthew R. McFarland, Frédéric Lamoliatte, +9

Vcp/p97-related ProcessesProtein AssemblyQuantitative DubStructural BioinformaticsMolecular Biology +16

Agonist-induced aggregation of Chinese hamster ovary cells coexpressing the human receptors for fibrinogen (integrin αIIbβ3) and the platelet-activating factor: dissociation between adhesion and aggregation

Susana Larrucea, Consuelo González‐Manchón, Nora Butta, +4

Blood