Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus

L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.

Joseph P. Vacca, Bruce D. Dorsey, William A. Schleif et al. · Proceedings of the National Academy of Sciences · 1994 · 526 citations · Full text

Immunology, Cell Culture, Pharmacotherapy +19

Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor

Jon H. Condra, Daniel Holder, William A. Schleif et al. · Journal of Virology · 1996 · 405 citations · Full text

Immunology, Vivo Viral Resistance, Molecular Biology +17

Clinically effective HIV-1 protease inhibitors

Joseph P. Vacca, Jon H. Condra · Drug Discovery Today · 1997 · 110 citations

Medicine, Immunology, Antiviral Drug Development +6

HIV Protease Inhibitors

Dale J. Kempf, Hing L. Sham · Current Pharmaceutical Design · 1996 · 100 citations

Hiv Protease Inhibitors, Immunology, Antiviral Drug +17

Non-active Site Changes Elicit Broad-based Cross-resistance of the HIV-1 Protease to Inhibitors

David B. Olsen, Mark W. Stahlhut, Carrie A. Rutkowski et al. · Journal of Biological Chemistry · 1999 · 74 citations · Full text