Concepedia

Inhibition of O6-Methylguanine-DNA Methyltransferase by Glucose-Conjugated Inhibitors: Comparison with Nonconjugated Inhibitors and Effect on Fotemustine and Temozolomide-Induced Cell Death

Bernd Kaina, Ute Mühlhausen, Andrea Piée‐Staffa, Markus Christmann, Regine García Boy, Frank Rösch, Ralf Schirrmacher

Journal of Pharmacology and Experimental Therapeutics · 2004 · 54 citations · 33 references

DOI

References

33

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

Manel Esteller, Stanley R. Hamilton, P C Burger et al. · PubMed · 1999 · 1.3K citations

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Over-expression of facilitative glucose transporter genes in human cancer

Taizo Yamamoto, Yutaka Seino, Hirofumi Fukumoto et al. · Biochemical and Biophysical Research Communications · 1990 · 468 citations

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Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

M. Eileen Dolan, Robert C. Moschel, Anthony E. Pegg · Proceedings of the National Academy of Sciences · 1990 · 459 citations · Full text

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Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study.

Kurt A. Jaeckle, Harmon J. Eyre, Jeannette J. Townsend et al. · Journal of Clinical Oncology · 1998 · 297 citations

Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine.

Michael Belanich, Monica Pastor, Terri Randall et al. · PubMed · 1996 · 246 citations

, , +12