Total Synthesis of the Potent Antitumor Macrolides Pladienolide B and D

Abstract

Getting cross: The total syntheses of two pladienolides (see picture), which have prominent antitumor activity based on a unique mechanism of action, have been accomplished, and their absolute configurations were verified. The 12-membered aliphatic macrolide structure was formed by ring-closing metathesis, and the side-chain moiety was coupled to the macrolide by Julia–Kocienski olefination or cross-metathesis. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z604997_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.