Total Synthesis of the Potent Antitumor Macrolides Pladienolide B and D

Regina Mikie Kanada, Daisuke Itoh, Mitsuo Nagai, +5

Angewandte Chemie International Edition

Medicinal ChemistryBioorganic ChemistryHeterocyclicRing-closing MetathesisDrug Discovery +13

Syntheses and Structure−Activity Relationships of 5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-quinoxaline Derivatives with Retinoic Acid Receptor α Agonistic Activity

K. Kikuchi, Shigeki Hibi, Hiroyuki Yoshimura, +5

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryDerivative (Chemistry)BiochemistryRetinoic Acid Receptor +12

A novel strategy for the stereoselective total synthesis of C-17 spiro steroids. Total synthesis of 19-norcanrenone - a formal total synthesis of 19-norspironolactone

Hideo Nemoto, Shigekazu Fujita, Mitsuo Nagai, +2

Journal of the American Chemical Society

Enantioselective SynthesisNovel StrategyBiochemistryNatural SciencesMedicine +12

First enantioselective total synthesis of (+)-cortisone

Hideo Nemoto, Norikazu Matsuhashi, Mari Imaizumi, +2

The Journal of Organic Chemistry

EngineeringAltmetric Attention ScoreBibliometricsOrganic ChemistryJ. Org +15

Discovery of Novel and Potent Retinoic Acid Receptor α Agonists:  Syntheses and Evaluation of Benzofuranyl-pyrrole and Benzothiophenyl-pyrrole Derivatives

Hiroyuki Yoshimura, K. Kikuchi, Shigeki Hibi, +8

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPharmaceutical ScienceDerivativesBenzothiophene Derivatives +13

Syntheses and Structure−Activity Relationships of Novel Retinoid X Receptor Agonists

Shigeki Hibi, K. Kikuchi, Hiroyuki Yoshimura, +3

Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryPharmaceutical ScienceBiochemistryNovel Retinoids +12

Acyclic Stereocontrol in Additions of Grignard Reagents to α-Alkoxyiminium Ions. A Stereoselective Approach to<i>threo</i>Amino Ethers

Mitsuo Nagai, John J. Gaudino, Craig S. Wilcox

Synthesis

Acyclic StereocontrolBioorganic ChemistryFace SelectivityBiochemistryEngineering +13

A highly stereoselective total synthesis of (±)-estrone and (±)-adrenosterone

Hideo Nemoto, Mitsuo Nagai, Mari Moizumi, +3

Tetrahedron Letters

Bioorganic ChemistryStereoselective Total SynthesisOrganic ChemistryStereoselective SynthesisPharmacology +2

High diastereoselection in the intramolecular Diels–Alder reaction of o-quinodimethanes: an expedient entry to trans-benzoperhydrindans. A highly stereoselective total synthesis of (±)-estrone and (±)-adrenosterone

Hideo Nemoto, Mitsuo Nagai, Mari Moizumi, +3

Journal of the Chemical Society Perkin Transactions 1

Bioorganic ChemistryDerivativesBiochemistrySubstituent EffectStereoselective Total Synthesis +12

Syntheses of bicyclo[3.3.0]octanes via bifurcating radical cyclization pathways

Mitsuo Nagai, Jerome Lazor, Craig S. Wilcox

The Journal of Organic Chemistry

Molecular SciencesHeterocyclicAlkene MetathesisBiochemistryDonut Icon +9