Concepedia

Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex

Michael S. South, Brenda L. Case, Rhonda S. Wood, Darin E. Jones, Michael Hayes, Thomas Girard, Rhonda M. Lachance, Nancy S. Nicholson, Michael Clare, Anna M. Stevens,

Bioorganic & Medicinal Chemistry Letters · 2003 · 42 citations · 29 references

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29

The refined 1.9 A crystal structure of human alpha‐thrombin: interaction with D‐Phe‐Pro‐Arg chloromethylketone and significance of the Tyr‐Pro‐Pro‐Trp insertion segment.

Wolfram Bode, Irmgard Mayr, Ulrich Baumann et al. · The EMBO Journal · 1989 · 893 citations · Full text

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The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

David W. Banner, A. D’Arcy, C. Chene et al. · Nature · 1996 · 733 citations

, , +15

Structure and Biology of Tissue Factor Pathway Inhibitor

Jens J. Birktoft, Sarah Steer, S Paul Bajaj et al. · Thrombosis and Haemostasis · 2001 · 218 citations

, , +16

Structure of human factor VIIa and its implications for the triggering of blood coagulation

A.C.W. Pike, A.M. Brzozowski, S.M. Roberts et al. · Proceedings of the National Academy of Sciences · 1999 · 134 citations

, , +16

Metabolism-Directed Optimization of 3-Aminopyrazinone Acetamide Thrombin Inhibitors. Development of an Orally Bioavailable Series Containing P1 and P3 Pyridines

Christopher S. Burgey, Kyle A. Robinson, Terry A. Lyle et al. · Journal of Medicinal Chemistry · 2003 · 121 citations · Full text

, , +17