Darin E. Jones

Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

Jerry H. Houl, Zu Ye, Chris A. Brosey et al. · Nature Communications · 2019 · 122 citations · Full text

Cloning and complete nucleotide sequence of a full-length cDNA encoding a catalytically functional tumor-associated aldehyde dehydrogenase.

Darin E. Jones, M D Brennan, J Hempel et al. · Proceedings of the National Academy of Sciences · 1988 · 90 citations · Full text

Full-length Cdna, Molecular Biology, Dimeric Enzyme +20

Design, Parallel Synthesis, and Crystal Structures of Pyrazinone Antithrombotics as Selective Inhibitors of the Tissue Factor VIIa Complex

John J. Parlow, Brenda L. Case, Thomas A. Dice et al. · Journal of Medicinal Chemistry · 2003 · 71 citations · Full text

Combinatorial Chemistry, Crystal Structure, Pharmacotherapy +16

Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation

Graciela B. Arhancet, Daniel P. Walker, Sue Metz et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 48 citations · Full text

Inflammation, Bioavailable Mpges-1 Inhibitor, Anti-inflammatory +8

Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer

Zhenfu Han, Peter K. Harris, Darin E. Jones et al. · ACS Medicinal Chemistry Letters · 2014 · 45 citations · Full text

Kinetic Enzyme, Pathology, Hgfa Inhibitors +23