Identification of Cytochrome P450 Isoforms Involved in Citalopram N-Demethylation by Human Liver Microsomes

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

S.M. de Morais, G. Wilkinson, Joyce Blaisdell et al. · Journal of Biological Chemistry · 1994 · 952 citations · Full text

Medicine, Genetics, Pharmacology +17

Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese.

G. Wilkinson, Joyce Blaisdell, Urs Meyer et al. · Molecular Pharmacology · 1994 · 750 citations

Life Sciences, Genetics, Pharmacology +16

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

F. Peter Guengerich, M V Martin, Philippe Beaune et al. · Journal of Biological Chemistry · 1986 · 730 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

Thomas Kronbach, Daniel Mathys, Makoto Umeno et al. · Molecular Pharmacology · 1989 · 535 citations

Medicine, Pharmacology, Biochemical Pharmacology +15

Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man

A. K�pfer, R Preisig · European Journal of Clinical Pharmacology · 1984 · 364 citations

Veterinary Medicine, Genetics, Pharmacology +10