Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

Kan Chiba, Anthony J. Trevor, Neal Castagnoli

Biochemical and Biophysical Research Communications

BiochemistryMedicineNeurotransmitterForensic ToxicologyNeuropharmacology +10

Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells

Yoshio Kameyama, Keiko Yamashita, Kaoru Kobayashi, +2

Pharmacogenetics and Genomics

Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations

Joyce A. Goldstein, Takashi Ishizaki, Kan Chiba, +4

Pharmacogenetics

Genotyping of S-mephenytoin 4′-hydroxylation in an extended Japanese population*

Takahiro Kubota, Kan Chiba, Takashi Ishizaki

Clinical Pharmacology & Therapeutics

Substrate Specificity of Carboxylesterase Isozymes and Their Contribution to Hydrolase Activity in Human Liver and Small Intestine

Teruko Imai, Megumi Taketani, Mayumi Shii, +2

Drug Metabolism and Disposition

Active uptake of MPP+, a metabolite of MPTP, by brain synaptosomes

Kan Chiba, Anthony J. Trevor, Neal Castagnoli

Biochemical and Biophysical Research Communications

NeurophysiologyMedicinePhysiologyNeurotransmitterBrain Synaptosomes +10

CYP2C9 Ile359 and Leu359 variants: enzyme kinetic study with seven substrates

Kenji Takanashi, Hitoshi Tainaka, Kaoru Kobayashi, +3

Pharmacogenetics

Leu359 VariantBiochemistryMedicineEnzyme Kinetic StudyNatural Sciences +11

Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat

Kaoru Kobayashi, Kikuko Urashima, Noriaki Shimada, +1

Biochemical Pharmacology

Molecular PharmacologyBiochemistryMedicineNatural SciencesSubstrate Specificity +7

Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-450 2A6 in human liver microsomes in vitro.

Kazumasa Ikeda, Kunihiro Yoshisue, Eiji Matsushima, +5

PubMed

Chemical BiologyToxicological MechanismMedicinal ChemistryBioanalysisToxicology +14

Human buprenorphine N-dealkylation is catalyzed by cytochrome P450 3A4.

Kaoru Kobayashi, Toshinori Yamamoto, Kan Chiba, +4

PubMed

PharmacotherapyChemical BiologyExperimental PharmacologyPharmaceutical ChemistryPharmacokinetics +14