Concepedia

Creation of an Amino Acid Network of Structurally Coupled Residues in the Directed Evolution of a Thermostable Enzyme

Manfred T. Reetz, Pankaj Soni, Juan Pablo Acevedo, Joaquı́n Sanchis

Angewandte Chemie International Edition · 2009 · 60 citations · 30 references

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Concepts

Abstract

Molecular orchestration: In the directed evolution of a hyperthermally stabilized enzyme, remote residues have been structurally coupled as a result of the creation of an extensive communicating amino acid network on the surface of the protein.

References

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