Structure-based design of thienobenzoxepin inhibitors of PI3-kinase

High Frequency of Mutations of the <i>PIK3CA</i> Gene in Human Cancers

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Medicine, Genetics, Oncology +11

PIK3CA is implicated as an oncogene in ovarian cancer

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The Identification of 2-(1<i>H</i>-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-<i>d</i>]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

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Medicine, Medicinal Chemistry, Pharmacology +13

Mutations in a signalling pathway

D. Williams Parsons, Tian‐Li Wang, Yardena Samuels et al. · Nature · 2005 · 634 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +8

Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis

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