Glyco‐SeS: Selenenylsulfide‐Mediated Protein Glycoconjugation—A New Strategy in Post‐Translational Modification

Abstract

Site-selective glycosylation by SeS-mediated ligation has led to the efficient formation of a wide variety of conjugates 1 without the need for a large excess of the carbohydrate reagent. By this convergent method it was possible to introduce a heptasaccharide glycan selectively, and to perform a multiple site-selective chemical glycosylation of protein. A chemically Cys-glycosylated glycoprotein was elaborated enzymatically. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z52975_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.