Transport Is Not Rate-Limiting in Morphine Glucuronidation in the Single-Pass Perfused Rat Liver Preparation

Morphine and metabolite behavior after different routes of morphine administration: Demonstration of the importance of the active metabolite morphine-6-glucuronide

Richard H. Osborne, Simon Joel, Duncan Trew et al. · Clinical Pharmacology & Therapeutics · 1990 · 448 citations

Medicine, Pharmacokinetics, Pharmacology +15

Human UGT2B7 catalyzes morphine glucuronidation.

Birgit L. Coffman, Gladys R. Rios, Christopher D. King et al. · PubMed · 1997 · 426 citations

Life Sciences, Biochemistry, Pharmacology +11

Determination of morphine, morphine-3-glucuronide and (tentatively) morphine-6-glucuronide in plasma and urine using ion-pair high-performance liquid chromatography

Jan‐Olof Svensson, Anders Rane, Juliette Säwe et al. · Journal of Chromatography B Biomedical Sciences and Applications · 1982 · 278 citations

Pharmacy, Pharmacokinetics, Pharmacology +11

Analgesic effects of morphine and morphine‐6‐glucuronide in a transcutaneous electrical pain model in healthy volunteers

Carsten Skarke, Jutta Darimont, Helmut Schmidt et al. · Clinical Pharmacology & Therapeutics · 2003 · 224 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Interaction of Morphine, Fentanyl, Sufentanil, Alfentanil, and Loperamide with the Efflux Drug Transporter P-glycoprotein

Christoph Wandel, Richard Kim, Margaret Wood et al. · Anesthesiology · 2002 · 215 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17