Birgit L. Coffman

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.

Lalitha Iyer, Christopher D. King, P. F. Whitington et al. · Journal of Clinical Investigation · 1998 · 680 citations · Full text

Medicine, Oncology, Pharmacology +17

Human UGT2B7 catalyzes morphine glucuronidation.

Birgit L. Coffman, Gladys R. Rios, Christopher D. King et al. · PubMed · 1997 · 426 citations

Life Sciences, Biochemistry, Pharmacology +11

The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268).

Birgit L. Coffman, Christopher D. King, Gladys R. Rios et al. · PubMed · 1998 · 326 citations

Medicine, Biochemistry, Pharmacology +13

The Glucuronidation of Exogenous and Endogenous Compounds by Stably Expressed Rat and Human UDP-Glucuronosyltransferase 1.1

Christopher D. King, Mitchell D. Green, Gladys R. Rios et al. · Archives of Biochemistry and Biophysics · 1996 · 159 citations

Life Sciences, Biochemistry, Molecular Biology +9

Differential glucuronidation of bile acids, androgens and estrogens by human UGT1A3 and 2B7

Walter Gall, Gregory Zawada, B. Mojarrabi et al. · The Journal of Steroid Biochemistry and Molecular Biology · 1999 · 145 citations

Life Sciences, Biochemistry, Endocrinology +14