Molecular Analysis of <i>tet</i> (W) Gene-Mediated Tetracycline Resistance in Dominant Intestinal <i>Bifidobacterium</i> Species from Healthy Humans

Abstract

tet(W) was found responsible for tetracycline resistance (MICs, 4 to > or =32 microg ml(-1)) in dominant bifidobacterial species from the gastrointestinal tracts of healthy humans. The gene from Bifidobacterium longum H66 proved to be identical over a 2.6-kbp region to the recently described tet(W) determinant of Butyrivibrio fibrisolvens.