Concepedia

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

Shiran Rabinovich, Lital N. Adler, Keren Yizhak, Alona Sarver, Alon Silberman, Shani Agron, Noa Stettner, Qin Sun, Alexander Brandis, Daniel Helbling,

Nature · 2015 · 392 citations · 21 references

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21

Global reconstruction of the human metabolic network based on genomic and bibliomic data

Natalie C. Duarte, Scott A. Becker, Neema Jamshidi et al. · Proceedings of the National Academy of Sciences · 2007 · 1.4K citations · Full text

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Metabolic Flux Balancing: Basic Concepts, Scientific and Practical Use

Amit Varma, Bernhard Ø. Palsson · Bio/Technology · 1994 · 945 citations

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Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

Issam Ben‐Sahra, Jessica J. Howell, John M. Asara et al. · Science · 2013 · 733 citations

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Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis

Aaron M. Robitaille, Stefan Christen, Mitsugu Shimobayashi et al. · Science · 2013 · 525 citations

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Predicting selective drug targets in cancer through metabolic networks

Ori Folger, Livnat Jerby, Christian Frezza et al. · Molecular Systems Biology · 2011 · 484 citations · Full text

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