Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

Shiran Rabinovich, Lital N. Adler, Keren Yizhak, +14

Nature

Ass1-deficient Tumours FostersEndocrine-related CancerOncogenic AgentMedicineMolecular Biology +7

Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

Joo Sang Lee, Lital N. Adler, Hiren Karathia, +31

Cell

UrologyBiochemical SignaturesRenal FunctionMedicineGenetics +5

MTCH2-mediated mitochondrial fusion drives exit from naïve pluripotency in embryonic stem cells

Amir Bahat, Andrés Goldman, Yehudit Zaltsman, +10

Nature Communications

Induction of Nitric-Oxide Metabolism in Enterocytes Alleviates Colitis and Inflammation-Associated Colon Cancer

Noa Stettner, Chava Rosen, Biana Bernshtein, +20

Cell Reports

Chemical Colitis ModelsChronic Inflammatory DiseasesNitric OxideImmunologyGastroenterology +16

Redox Modulation of Adjacent Thiols in VLA-4 by AS101 Converts Myeloid Leukemia Cells from a Drug-Resistant to Drug-Sensitive State

Adi Layani-Bazar, Itai Skornick, Alain Berrébi, +7

Cancer Research

Chemoprevention StrategyMixed-phenotype Acute LeukemiaIntegrin Vla-4Redox BiologyTumor Biology +15

Acid-Induced Downregulation of ASS1 Contributes to the Maintenance of Intracellular pH in Cancer

Alon Silberman, Omer Goldman, Odeya Boukobza Assayag, +19

Cancer Research

Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy

Giuseppe Lonetto, Gabriela Koifman, Alon Silberman, +7

Cell Death and Differentiation

Mutant P53Tumor BiologyMitochondrial FunctionMitochondrial DynamicMedicine +13

The Anticancer Activity of Organotelluranes: Potential Role in Integrin Inactivation

Alon Silberman, Yona Kalechman, Shira Hirsch, +3

ChemBioChem

Medicinal ChemistryLabile LigandsChemoprevention StrategyMedicineIntegrin Inactivation +11

The mitochondrial carrier Citrin plays a role in regulating cellular energy during carcinogenesis

Shiran Rabinovich, Alon Silberman, Lital N. Adler, +12

Oncogene

MitophagyMitochondrial FunctionMitochondrial Carrier CitrinSystems BiologyMedicine +4

8-(p-CF3-cinnamyl)-modified purine nucleosides as promising fluorescent probes

Lital Zilbershtein, Alon Silberman, Bilha Fischer

Organic & Biomolecular Chemistry