Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

Shiran Rabinovich, Lital N. Adler, Keren Yizhak, +14

Nature

Ass1-deficient Tumours FostersEndocrine-related CancerOncogenic AgentMedicineMolecular Biology +7

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

Simon Raffel, Mattia Falcone, Niclas Kneisel, +31

Nature

Idhmut-like Dna HypermethylationChromatinTranscriptional RegulationGenome InstabilityαKg Levels +12

Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

Joo Sang Lee, Lital N. Adler, Hiren Karathia, +31

Cell

UrologyBiochemical SignaturesRenal FunctionMedicineGenetics +5

Arabidopsis VTC2 Encodes a GDP-l-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants

Carole L. Linster, Tara A. Gomez, Kathryn C. Christensen, +4

Journal of Biological Chemistry

Ascorbic AcidPlant Molecular BiologyBiosynthesisLast Unknown EnzymeEngineering +9

Systems and <i>Trans</i>-System Level Analysis Identifies Conserved Iron Deficiency Responses in the Plant Lineage

Eugen I. Urzica, David Casero, Hiroaki Yamasaki, +8

The Plant Cell

BotanyIron MetabolismGeneticsMolecular BiologyGenomics +19

The MHC class II antigen presentation pathway in human monocytes differs by subset and is regulated by cytokines

Justin Lee, H.K. Tam, Lital N. Adler, +3

PLoS ONE

Adaptive Immune SystemHla ImmunogeneticsImmunologyImmune RegulationPathology +17

Impact of Oxidative Stress on Ascorbate Biosynthesis in Chlamydomonas via Regulation of the VTC2 Gene Encoding a GDP-l-galactose Phosphorylase

Eugen I. Urzica, Lital N. Adler, M. Dudley Page, +6

Journal of Biological Chemistry

Plant PhysiologyAscorbate PeroxidaseRedox BiologyOxidative StressPlant Molecular Biology +14

Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors

Rom Keshet, Joo Sang Lee, Lital N. Adler, +27

Nature Cancer

Purine SynthesisCheckpoint InhibitorsMedicineImmunologyImmune Checkpoint Inhibitor +7

In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls

Wei Jiang, James R. Birtley, Shu-Chen Hung, +15

Nature Communications

Lung dendritic-cell metabolism underlies susceptibility to viral infection in diabetes

Samuel Philip Nobs, Aleksandra A. Kolodziejczyk, Lital N. Adler, +27

Nature