Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Anna Paczulla, Kathrin Rothfelder, Simon Raffel, +24

Nature

Immune EvasionCell TherapyMedicineStem Cell TransplantationImmunology +3

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

Simon Raffel, Mattia Falcone, Niclas Kneisel, +31

Nature

Idhmut-like Dna HypermethylationChromatinTranscriptional RegulationGenome InstabilityαKg Levels +12

Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma

Chiara Ambrogio, Gonzalo Goméz-López, Mattia Falcone, +14

Nature Medicine

Tumor BiologyMedicineTherapeutic StrategyKras-driven Lung AdenocarcinomaBronchial Neoplasm +9

Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin

Elisa Espinet, Zuguang Gu, Charles D. Imbusch, +35

Cancer Discovery

Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells

Alice C. Newman, Mattia Falcone, Alejandro Huerta Uribe, +6

Molecular Cell

Cancer ResearchPancreatic CancerOne-carbon UnitsBiochemistryMedicine +13

Quantitative proteomics reveals specific metabolic features of acute myeloid leukemia stem cells

Simon Raffel, Daniel Klimmeck, Mattia Falcone, +18

Blood

Inhibition of DDR1 enhances in vivo chemosensitivity in KRAS-mutant lung adenocarcinoma

Marie‐Julie Nokin, Élodie Darbo, Camille Travert, +18

JCI Insight

ImmunologyImmunoeditingVivo ChemosensitivityCancer BiologyTumor Biology +18

Sensitisation of cancer cells to radiotherapy by serine and glycine starvation

Mattia Falcone, Alejandro Huerta Uribe, Alice C. Newman, +13

British Journal of Cancer

Tissue-specific control of midbody microtubule stability by Citron kinase through modulation of TUBB3 phosphorylation

Francesco Sgrò, F. Bianchi, Mattia Falcone, +8

Cell Death and Differentiation

Signal TransductionEngineeringCell SignalingMedicineCitron Kinase +10

Phenotypic profiling of solute carriers characterizes serine transport in cancer

Alice C. Newman, Alejandro Huerta Uribe, Nathalie Legrave, +8

Nature Metabolism