Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

Alexandre Calon, Enza Lonardo, Antonio Berenguer, +16

Nature Genetics

MedicinePathologyColorectal CancerCancer GenomicsCancer Genetics +3

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

Alexandre Calon, Elisa Espinet, Sergio Palomo‐Ponce, +14

Cancer Cell

Tumor BiologyOncologyTgf-β-driven ProgramMedicineCancer Cell Biology +7

Endothelial Notch1 Activity Facilitates Metastasis

Elfriede Wieland, Juan Rodríguez‐Vita, Sven S. Liebler, +16

Cancer Cell

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CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma

Elisa M. Noll, Christian Eisen, Albrecht Stenzinger, +27

Nature Medicine

Tumor BiologyOncologyPancreatic CancerMedicinePathology +6

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors

Magdolna Djurec, Osvaldo Graña‐Castro, Albert Lee, +18

Proceedings of the National Academy of Sciences

Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin

Elisa Espinet, Zuguang Gu, Charles D. Imbusch, +35

Cancer Discovery

TNF-α-producing macrophages determine subtype identity and prognosis via AP1 enhancer reprogramming in pancreatic cancer

Mengyu Tu, Lukas Klein, Elisa Espinet, +18

Nature Cancer

Pancreatic CancerMedicineSubtype IdentityImmunologyPathology +6

Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis

Mahak Singhal, Nicolas Gengenbacher, Ashik Ahmed Abdul Pari, +21

Science Translational Medicine

LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma

Hamed Alborzinia, Zhiyi Chen, Umut Yildiz, +30

EMBO Molecular Medicine

HAPLN1 potentiates peritoneal metastasis in pancreatic cancer

Lena Wiedmann, Francesca Rigotti, Nuria Vaquero‐Siguero, +15

Nature Communications