α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

Haiping Wang, Xiaoyun Li, Tung Chao, +13

Nature Immunology

Epigenetic ReprogrammingMetabolic RegulationMetabolismMedicineCell Biology

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

Sandra Schoors, Ulrike Brüning, Rindert Missiaen, +21

Nature

AngiogenesisFatty Acid CarbonBiochemistryEndothelial CellsNatural Sciences +9

Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis

Aaron M. Robitaille, Stefan Christen, Mitsugu Shimobayashi, +7

Science

Signal TransductionSignaling PathwayBiochemistryNatural SciencesReceptor Tyrosine Kinase +12

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

Kim Vriens, Stefan Christen, Sweta Parik, +43

Nature

Lineage PlasticityLipid SynthesisOmega-3 Fatty AcidMedicineCancer Cell Biology +6

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

Ilaria Elia, Dorien Broekaert, Stefan Christen, +6

Nature Communications

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

Edouard Mullarky, Natasha C. Lucki, Reza Beheshti Zavareh, +15

Proceedings of the National Academy of Sciences

EngineeringAldo-keto ReductaseSmall Molecule InhibitorSerine BiosynthesisCancer Biology +18

Short-Term Oral Endothelin-Receptor Antagonist Therapy in Conventionally Treated Patients With Symptomatic Severe Chronic Heart Failure

Gabor Sütsch, Wolfgang Kiowski, Xiao-Wei Yan, +6

Circulation

Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

Sophia Y. Lunt, Vinayak Muralidhar, Aaron M. Hosios, +19

Molecular Cell

Impact Cell ProliferationCell RegulationBiochemistryNatural SciencesGene Expression +9

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

Stefan Christen, Doriane Lorendeau, Roberta Schmieder, +10

Cell Reports

Intracellular characterization of aerobic glucose metabolism in seven yeast species by 13C flux analysis and metabolomics

Stefan Christen, Uwe Sauer

FEMS Yeast Research

Microbial MetabolismMetabolic ModelGradual TransitionAerobic Glucose MetabolismSecondary Metabolism +18