Concepedia

Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver

Kota Kato, Masato Ohbuchi, Satoko Hamamura, Hiroki Ohshita, Yasuhiro Kazuki, Mitsuo Oshimura, Koya Sato, Naoyuki Nakada, Akio Kawamura, Takashi Usui,

Drug Metabolism and Disposition · 2015 · 29 citations · 24 references

DOI

Concepts

References

24

Near Completely Humanized Liver in Mice Shows Human-Type Metabolic Responses to Drugs

Chise Tateno, Yasumi Yoshizane, Naomi Saito et al. · American Journal Of Pathology · 2004 · 545 citations

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Assessment of Three Human in Vitro Systems in the Generation of Major Human Excretory and Circulating Metabolites

Deepak Dalvie, R. Scott Obach, Ping Kang et al. · Chemical Research in Toxicology · 2009 · 187 citations

, , +17

Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms.

Perloff, von Moltke Ll, MH Court et al. · PubMed · 2000 · 166 citations

, , +13

Midazolam and Triazolam Biotransformation in Mouse and Human Liver Microsomes: Relative Contribution of CYP3A and CYP2C Isoforms

Michael Perloff, Lisa L. von Moltke, Michael H. Court et al. · Journal of Pharmacology and Experimental Therapeutics · 2000 · 122 citations

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EXPRESSION OF HUMAN CYTOCHROMES P450 IN CHIMERIC MICE WITH HUMANIZED LIVER

Miki Katoh, Tomohito Matsui, Miki Nakajima et al. · Drug Metabolism and Disposition · 2004 · 114 citations

, , +17