EXPRESSION OF HUMAN CYTOCHROMES P450 IN CHIMERIC MICE WITH HUMANIZED LIVER

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

Ulrich K. Laemmli · Nature · 1970 · 251.6K citations

Life Sciences, Microbiology, Molecular Biology +14

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

Peter Kuehl, Jiong Zhang, Yvonne Lin et al. · Nature Genetics · 2001 · 2.2K citations

Life Sciences, Genetics, Molecular Biology +17

Hepatitis C virus replication in mice with chimeric human livers

David F. Mercer, Dan Schiller, John F. Elliott et al. · Nature Medicine · 2001 · 877 citations

Life Sciences, Infectious Diseases, Microbiology +13

Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese.

G. Wilkinson, Joyce Blaisdell, Urs Meyer et al. · Molecular Pharmacology · 1994 · 750 citations

Life Sciences, Genetics, Pharmacology +16

Near Completely Humanized Liver in Mice Shows Human-Type Metabolic Responses to Drugs

Chise Tateno, Yasumi Yoshizane, Naomi Saito et al. · American Journal Of Pathology · 2004 · 545 citations

Medicine, Pharmacokinetics, Pharmacology +12