Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: Introduction of an additional carboxyl group at the C-2 position of quinoline

Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1

Yujiang Geno Shi, Yujiang Geno Shi, Fei Lan et al. · Cell · 2004 · 4K citations · Full text

Life Sciences, Genetics, Molecular Biology +11

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

M.A. McDonough, Vivian Li, Emily Flashman et al. · Proceedings of the National Academy of Sciences · 2006 · 368 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

Stanley S. Ng, K.L. Kavanagh, M.A. McDonough et al. · Nature · 2007 · 324 citations

Life Sciences, Genetics, Molecular Biology +15

Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases

Nathan R. Rose, Stanley S. Ng, Jasmin Mecinović et al. · Journal of Medicinal Chemistry · 2008 · 249 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +11

Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases

Rasheduzzaman Chowdhury, M.A. McDonough, Jasmin Mecinović et al. · Structure · 2009 · 238 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14